Instructions for Debian Linux

apt-get install wine libwine wine-doc wine-utils winesetuptk xwine

Then you run wineinstall. Make sure to configure the COM ports. In ~/.wine/config it looks like:

"Com1" = "/dev/ttyS0"

Possibly /dev/ttyUSB0 or /dev/ttyUSB1 if you use USB-RS232 module. Make sure the serial port works from linux - eg. modprobe pl2303 might be needed (edit /etc/modules, whatever) before trying to make it work from wine.

Start MegaTune under Wine... I used a normal user account (not root). The user needs access to the chosen serial port ("rw" rights to /dev/ttyS0 in my case, granted via group membership)

The above was verified by others to work.

However, if you run into any troubles, please post here or ask in IRC.